Preimplantation genetic testing of embryos is an option offered at Main Line Fertility that increases the possibility of a successful pregnancy with in vitro fertilization (IVF). PGT can help identify embryos that have genetic abnormalities that can result in a miscarriage or a genetic disorder, such as Downs Syndrome or Cystic Fibrosis. Additionally, genetic testing allows patients to know the gender of the embryos if they wish.

TYPES OF PGT

PGT-A (ANEUPLOIDY)
Screens for aneuploidy which is too few or too many chromosomes. Aneuploidy can lead to IVF failure or miscarriage and occurs randomly in embryos during development.

 

PGT-M (MONOGENIC/SINGLE GENE)
Diagnoses specific genetic disorders in embryos such as Cystic Fibrosis, Fragile X, Muscular Dystrophy, BRCA, Thalassemia, Tay Sachs and others.

 

PGT-SR (STRUCTURAL REARRAGNEMENTS)
Identifies whether the embryo has a structural rearrangement of its chromosomal matter. PGT-SR can be performed to improve the chance of establishing a healthy pregnancy for people with a chromosomal translocation.

“We chose to do preimplantation genetic testing on our embryos because we wanted to have the best chance for a successful and healthy pregnancy”

– Ashley & Mike

PATIENTS WHO MAY CHOOSE TO DO PGT INCLUDE

      • Female patients over the age of 34
      • Patients who have experienced repeated IVF failure
      • Patients or partners who are carriers or affected by genetic disorders that can be passed down to a child
      • Patients or partners who are carriers of a translocation
      • Patients with a history of miscarriage
      • Patients who do not want to incur cryostorage fees of chromosomally abnormal embryos
      • Patients who wish to reduce their risk of miscarriage and genetic abnormalities
      • Patients interested in gender selection for family balancing

HOW PGT IS PERFORMED

To perform preimplantation genetic testing, embryologists remove a small sample of cells from the outer layer (called the trophectoderm) of a blastocyst on day 5, day 6, or day 7 of culture. The blastocyst is frozen after the sample is removed and remains at Main Line Fertility’s laboratory. The biopsy is sent to a laboratory for genetic testing.

INVESTMENT

The cost of preimplantation genetic testing begins at $3,200 and includes the biopsy, shipping of samples to the genetic laboratory, and testing. The final cost of PGT is dependent on how many embryos are tested. We offer a banking option for patients undergoing multiple IVF cycles.

FREQUENTLY ASKED QUESTIONS

Not all embryos created will develop to the blastocyst stage. Only good quality blastocysts on day 5, day 6 or day 7 of culture can be biopsied.

PGT reduces the chance of having a chromosomally abnormal pregnancy but does not replace prenatal testing.

Your Main Line Fertility physician will partner with you to decide if PGT is beneficial based on your medical history and personal preferences.

Some insurances will cover PGT. Patients should contact their insurance carriers to determine coverage prior to their IVF cycle.

PGT is able to identify the gender of your embryo(s), and if you wish to know the gender we can share that information with you. Patients can specify the gender they prefer for embryo transfer. We are not able to change or guarantee a gender.

Yes, we are able to perform PGT on frozen embryos by thawing the embryos and performing the biopsy.

While PGT can greatly reduce your chance of experiencing a miscarriage or having a child with a genetic disorder, it cannot guarantee that they will not occur.

Questions about preimplantation genetic testing?
Email us at pgt@mainlinefertility.com